Calvi BR et al. 1991
- Authors:
Calvi BR. Hong TJ. Findley SD. Gelbart WM.
- Title:
Evidence for a common evolutionary origin of inverted repeat transposons
in Drosophila and plants: hobo, Activator, and Tam3.
- Reference location:
Cell. 66(3):465-71, 1991 Aug 9.
- Abstract:
We have sequenced HFL1 from D. melanogaster, the only cloned hobo element
shown to have transposase activity. The 2959 bp HFL1 sequence predicts a
2.0 kb open reading frame (ORF1) with substantial amino acid similarity to
the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from
snapdragon (Antirrhinum majus). Mutational analysis of a C-terminal region
of ORF1 conserved with Ac and Tam3 indicates that it is essential for hobo
transposase activity. This is an example of extensive amino acid sequence
identity between short inverted repeat elements in different kingdoms. We
discuss the possibility that the conservation of hobo, Ac, and Tam3
transposases represents an example of horizontal transmission of genetic
information between plants and animals.
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